Profile
Dr Hwee Kuan LEE
Principal Investigator
Dr Hwee Kuan Lee current research work involves the development of Artificial Intelligence (AI) research for clinical and biological applications. His laboratory focus on diverse research activities, including more basic AI centric research as well as AI applications. Theoretical AI development activities in Lee’s laboratory is mostly inspired by impactful clinical use cases. Clinical application areas include diagnostics in cancers, cardiology, dermatology and interventional radiology. In the area of biology, Lee’s laboratory develops bioinformatics pipelines in spatial omics and single cell analysis, and in the development of AI in protein science and drug discovery.
Hwee Kuan’s primary appointment is as the Deputy Director for Training and Talent development in the Bioinformatics Institute (Agency for Science, Technology and Research). He also holds multiple adjunct and joint appointments in the local universities and other research institutions.
leehk@a-star.edu.sg
Singapore
Principal Investigators
BloodCounts!
Research Interest
Key Publications
Baskaran L, Leng S, Dutta U, Teo L, Yew MS, Sia H, Chew N, Huang W, Lee HK, Vaughan R, Ngiam KY, Lu Z, Wang X, Tan EWP, Cheng NZY, Tan SY, Chan M, Zhong L. Cohort profile: AI-driven national Platform for CCTA for clinicaL and industriaL applicatiOns (APOLLO). BMJ Open, 2024 Nov
Huo X, Ong KH, Lau KW, Gole L, Young DM, Tan CL, Zhu X, Zhang C, Zhang Y, Li L, Han H, Lu H, Zhang J, Hou J, Zhao H, Gan H, Yin L, Wang X, Chen X, Lv H, Cao H, Yu X, Shi Y, Huang Z, Marini G, Xu J, Liu B, Chen B, Wang Q, Gui K, Shi W, Sun Y, Chen W, Cao D, Sanders SJ, Lee HK, Hue SSS, Yu W, Tan SY. A comprehensive AI model development framework for consistent Gleason grading. Commun Med. 2024 May 9;4(1):84.
Singhal V, Chou N, Lee J, Yue Y, Liu J, Chock WK, Lin L, Chang YC, Teo EML, Aow J, Lee HK, Chen KH, Prabhakar S. BANKSY unifies cell typing and tissue domain segmentation for scalable spatial omics data analysis. Nat Genet. 2024 Mar;56(3):431–441.
Oner MU, Kye-Jet JMS, Lee HK, Sung WK. Distribution based MIL pooling filters: Experiments on a lymph node metastases dataset. Med Image Anal. 2023 Jul;87:102813. PMID: 37120993.
Paknezhad M, Rengarajan H, Yuan C, Suresh S, Gupta M, Ramasamy S, Lee HK. Improving transparency and representational generalizability through parallel continual learning. Neural Netw. 2023 Apr;161:449-465. PMID: 36805261.