Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology
Profile


Dr Suthesh SIVAPALARATNAM
Principal Investigator
Dr Suthesh Sivapalaratnam is a clinician scientist specialising in haemostasis, thrombosis, genomics and artificial intelligence in healthcare. His clinical practice spans paediatric and adult haemostasis and thrombosis at one of the world’s largest haemophilia centres, caring for more than 2,350 patients with rare bleeding disorders. He is currently Academic Lead for Clinical Haematology and previously served as genomics and paediatrics lead, where he established the first monthly pan-London haemostasis and thrombosis genomics MDT.
Dr Sivapalaratnam studied Medicine at the University of Amsterdam and completed a PhD fellowship at the Academic Medical Center, conducting research between the University of Cambridge and the University of Amsterdam on the molecular basis of early-onset cardiovascular disease. He later completed a postdoctoral fellowship at the Massachusetts General Hospital and the Broad Institute before returning to Cambridge to focus on the genetics of rare inherited bleeding and platelet disorders. In 2015, he was awarded a prestigious TRTH Fellowship from the American Society of Hematology and the European Hematology Association.
His current research focuses on harnessing large-scale data, including genomic and multi-omic data to improve patient outcomes through earlier detection, precision diagnostics and personalised care. He is Deputy Chair of the BloodCounts! Consortium, which is developing a foundation model of blood and has secured funding from the Trinity Challenge and the Gates Foundation. He also leads national recall studies in haemostasis and thrombosis, integrating proteomics, RNA sequencing, and whole-genome sequencing in unexplained cases, and is Chief Investigator for Sutacimig, the first-in-class prophylactic treatment for Glanzmann thrombasthenia and Factor VII deficiency.
He serves as Co-Chair of the genomics SSC for the International Society on Thrombosis and Haemostasis and EAHAD, Chair of its Standing Committee on AI and ML, and Chair of the UKHCDO Genomics Working Party.
UK
Principal Investigators
BloodCounts!
Key Publications
Turro E et al. Whole-genome sequencing of patients with rare diseases in a national health system. Nature. Jul 2020
Bowles L et al. Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19. N Engl J Med. May 2020
Lentaigne C, Greene D, Sivapalaratnam S et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. Dec 2019
Downes K et al. Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. Blood. Dec 2019
Deltadahl et al., Deep Generative Classification of Blood Cell Morphology, under review at Nature Machine Intelligence, Feb. 2025
Achievements
NIHR Academic Clinical Fellowship award, 2016
ASH-EHA Translational Research Training in Hematology