Profile
Assoc Prof Christopher CHEN Li-Hsian
Collaborator
Dr Christopher Chen Li-Hsian studied for the Medical and Natural Science Tripos at Fitzwilliam College, Cambridge University, and graduated with a Second Upper in Physiology & Psychology in 1982. His clinical training was at the University of Oxford where he obtained his BMBCh in 1985. He is currently an Associate Professor at the Department of Pharmacology and Director of the Memory Aging and Cognition Centre, National University Health System.
Since returning to Singapore in 1995, Dr Chen has developed a comprehensive multi-disciplinary dementia programme and encouraged collaborative research in the Asia-Pacific region and beyond. His current focus is on developing a regional network for innovative trials into conditions prevalent and pertinent to Asia. In addition, he has developed a Trials Unit focusing on stroke and dementia with wide international collaborations.
His major research and clinical interests are in neurochemistry, molecular biology and treatment of stroke and dementia. He has published over 250 peer-reviewed papers and book chapters, served on several editorial boards (Stroke, Journal of Neurology Neurosurgery and Psychiatry), trial steering committees and data safety monitoring boards. He is currently the Principal Investigator of the CHIMES trials, which has extensive international collaborations.
Dr Chen has also developed an international reputation for participation in academically driven as well as industry sponsored clinical trials. His aim is to develop synergies with basic neuroscience research and to translate novel scientific findings into therapeutic possibilities as well as to provide clinical insights for disease specific laboratory research.
Apart from international collaborative research programmes, Dr Chen works very closely with scientists from A*STAR and NUS. They have been studying biochemical and genetic markers underlying the pathophysiology of stroke. Longitudinal studies are also in progress to study the natural history, risk factors for and treatment to prevent cognitive impairment and dementia after stroke.
phccclh@nus.edu.sg
Singapore
Collaborators
BloodCounts!
Research Interest
Key Publications
Google Scholar Link
Sim MA, Tham YC, Nusinovici S, Quek TC, Yu M, Xue CC, Chee ML, Peng QS, Tan ESJ, Chan SP, Cai Y, Chong EJY, Tan BY, Venketasubramanian N, Hilal S, Lai MKP, Choi H, Richards AM, Cheng CY, Chen CLH. A deep-learning retinal aging biomarker for cognitive decline and incident dementia. Alzheimer's &
Dementia (2025)
Chua J, Li C, Antochi F, Toma E, Wong D, Tan B, Garhöfer G, Hilal S, Popa-Cherecheanu A, Chen CL, Schmetterer L. Utilizing Deep Learning to Predict Alzheimer's Disease and Mild Cognitive Impairment with Optical Coherence Tomography. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 17 (2025) e70041
Wu Y, Dong Z, Li HB, Chong YF, Ji F, Chong JSX, Tang NRJ, Hilal S, Fu H, Chen CL, Zhou JH; Alzheimer's Disease Neuroimaging Initiative. WMH-DualTasker: A weakly-supervised deep learning model for automated white matter hyperintensities segmentation and visual rating prediction. Human Brain Mapping 15 (2025) e70212
Srikrishna M, Ashton NJ, Moscoso A, Pereira JB, Heckemann RA, van Westen D, Volpe G, Simrén J, Zettergren A, Kern S, Wahlund LO, Gyanwali B, Hilal S, Ruifen JC, Zetterberg H, Blennow K, Westman E, Chen C, Skoog I, Schöll M. CT-based volumetric measures obtained through deep learning: association with biomarkers of neurodegeneration. Alzheimer’s and Dementia 20 (2024) 629-640
Lee LY, Vaghari D, Burkhart MC, Tino P, Montagnese M, Li Z, Zühlsdorff K, Giorgio J, Williams G, Chong E, Chen C, Underwood BR, Rittman T, Kourtzi Z. Robust and interpretable AI-guided marker for early dementia prediction in real-world clinical settings. EClinicalMedicine 74 (2024) 102725
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Achievements
- Singapore Translational Research Investigator Award, National Medical Research Council
- Senior Clinician Scientist Award, Biomedical & National Medical Research Councils
- Graduate Mentor Award, National University Medicine
- Faculty Research Award, Yong Loo Lin School of Medicine
- College of Physicians Lecturer, Singapore
- Galloway Memorial Lecturer, Academy of Medicine Singapore
- Gilberto L. Gamez Memorial Lecturer, Philippine Neurological Association
- K3Simeon Marasigan Memorial Lecturer, Dementia Society of the Philippines