Dr Guoying CHEN

Research Fellow

Dr Chen obtained his PhD from National University of Singapore in 2012, majoring in organic chemistry. After graduation, he joined Experimental Therapeutic Centre, ASTAR as a medicinal chemist, doing fragment-based drug discovery. He then worked as process chemist at a drug manufacture. Before joining CARES, he was a consultant at BIPO Singapore. My role at CARES is to develop novel process for drugs using digital workflow.

Singapore - CARES



Research Interest

- Using machine learning to study the synthetic process for small molecule drug
- Process chemistry in the application of pharmaceutical industry
- High throughput experiment platform application

Key Publications

Chen, G.-Y., Ng, F.M., Tan, Y.W., Poulsen, A., Seetoh, W., Lin, G., Kang, C., Then, S.W., Ahmad, N.H., Wong, Y.L., Ng, H.Q., Chia, C.S.B., Lau, Q.Y., Hill, J., Hung, A.W. and Keller, T.H. (2015), Application of Fragment-Based Drug Discovery against DNA Gyrase B. ChemPlusChem, 80: 1250-1254.

Guo-Ying Chen, Fangrui Zhong, and Yixin Lu. 2012. Asymmetric Allylic Alkylation of Isatin-Derived Morita–Baylis–Hillman Carbonates with Nitroalkanes, Organic Letters, 14(15), 3955-3957, DOI: 10.1021/ol301962e

Wei Zeng, Guo-Ying Chen, Yong-Gui Zhou, and Yu-Xue Li. 2007. Hydrogen-Bonding Directed Reversal of Enantioselectivity, Journal of the American Chemical Society, 129(4), 750-751, DOI: 10.1021/ja067346f