Profile

Dr Guoying CHEN

Research Fellow

Dr Chen obtained his PhD from National University of Singapore in 2012, majoring in organic chemistry. After graduation, he joined Experimental Therapeutic Centre, ASTAR as a medicinal chemist, doing fragment-based drug discovery. He then worked as process chemist at a drug manufacture. Before joining CARES, he was a consultant at BIPO Singapore. My role at CARES is to develop novel process for drugs using digital workflow.

Singapore - CARES

Researchers

PIPS

Research Interest

- Using machine learning to study the synthetic process for small molecule drug
- Process chemistry in the application of pharmaceutical industry
- High throughput experiment platform application

Key Publications

Chen, G.-Y., Ng, F.M., Tan, Y.W., Poulsen, A., Seetoh, W., Lin, G., Kang, C., Then, S.W., Ahmad, N.H., Wong, Y.L., Ng, H.Q., Chia, C.S.B., Lau, Q.Y., Hill, J., Hung, A.W. and Keller, T.H. (2015), Application of Fragment-Based Drug Discovery against DNA Gyrase B. ChemPlusChem, 80: 1250-1254. https://doi.org/10.1002/cplu.201500197


Guo-Ying Chen, Fangrui Zhong, and Yixin Lu. 2012. Asymmetric Allylic Alkylation of Isatin-Derived Morita–Baylis–Hillman Carbonates with Nitroalkanes, Organic Letters, 14(15), 3955-3957, DOI: 10.1021/ol301962e


Wei Zeng, Guo-Ying Chen, Yong-Gui Zhou, and Yu-Xue Li. 2007. Hydrogen-Bonding Directed Reversal of Enantioselectivity, Journal of the American Chemical Society, 129(4), 750-751, DOI: 10.1021/ja067346f

Achievements